Open Clinical Trials & Investigator-Initiated Studies

For more information about currently open studies or studies that may be opening soon, please contact the Clinical Research Center by phone (207) 973-9033 or e-mail wcurrier@emhs.org.

All Active, IRB-approved Studies by Service Area:
The Efficacy of a Pharmacist-led Smoking Cessation Intervention for Oncology Patients.

Micronutrients as Adjunctive Treatment for Bipolar Disorder.

A Brief Intervention for Mindfulness-Based Rel
apse Prevention in Primary Care: A Feasibility Pilot Study for Patients in Treatment for Opiate Addiction with Buprenorphine.

 
Care Plan Program to Reduce Non-urgent Emergency Department Utilization among Super Utilizers.


 
TrialNet - Natural History Study of the Development of Type 1 Diabetes.

 
Prevalence and Predictors of Oral Feeding Intolerance in Acute Pancreatitis: A Retrospective Study in a Tertiary Care Referral Center.

APPRENTICE: Acute Pancreatitis Patient Registry to Examine Novel Therapies in Clinical Experience.


 
Geriatric Psychiatry:
A Phase 3 Safety and Efficacy Study of ALZT‐OP1 in Subjects with Evidence of Early Alzheimer’s Disease.

EARLY -
A Phase 2b/3 Randomized, Double-blind, Placebo-Controlled, Parallel Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects who are Asymptomatic At Risk for Developing Alzheimer’s Dementia.

A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer's Disease Dementia (The DAYBREAK Study).

HARMONY - A Double-blind, Placebo-controlled, Relapse Prevention Study of Pimavanserin for the Treatment of Hallucinations and Delusions Associated With Dementia-related Psychosis.

A Phase 2A Multicenter, Randomized, Double-blind, Parallel Group, 26-Week, Placebo-controlled Study of 50 mg and 100 mg of SUVN-502 in Subjects with Moderate Alzheimer's Disease Currently Treated with Donepezil Hydrochloride and Memantine Hydrochloride.

A 52-Week Open-label Extension Study of Pimavanserin for the Treatment of Agitation and Aggression in Subjects with Alzheimer's Disease.

Long-term Nicotine Treatment of Mild Cognitive Impairment.

 

Multi-Center Collaborative to Move Beyond Mortality Review and Create the Next Generation Safety Learning System

MaineCares: A Partnership for Primary Care Education.

Impact of Reflective Writing on the Development of Interprofessional Communication Skills and Relationships Within Teams.

Epidemiological Characteristics of Stroke - Retrospective Review of 5-Year Data (2010-2016) from Hospitals in Maine.

Mild and Rapidly Improving Stroke Study (MaRISS).


Management of Acute Stroke Patients on Treatment with New Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) Registry.

Management of Parkinson's Disease Psychosis in Actual Practice (The INSYTE Study).

Long-term, Prospective, Multinational, Parallel-cohort Study Monitoring Safety in Patients with MS Newly Started on Fingolimod Once Daily or Treated with Another Approved Disease-modifying Therapy.
A Program to Improve Bone Health after a Fragility Fracture by Increasing Patient Access to Quality Evidence-based Care through a Fracture Liaison Service to Promote Secondary Fragility Fracture Prevention.

A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System.

A Prospective Post-market, Multi-center Study of the Tritanium® Acetabular Shell.

Screening for Osseous Lesions after Anterior Shoulder Dislocation.

 
Effects of Osteopathic Manipulative Treatment (OMT) on Post-Operative Ileus: A Prospective Study.
The Impact of Disparities in Time to Initiation of Neonatal Hypothermia in Rural Settings - A Retrospective Chohort Study.

The Way to Optimal Weight (WOW): A Multidisciplinary Weight Loss Intervention for Overweight and Obese Children.

Pediatric Obesity Weight Evaluation Registry (POWER): A Prospective Pilot Project of Children and Adolescents Presenting for Weight Management.

Care Coordination of Services for Children with Autism Spectrum Disorders.


Community-based Outpatient Clinic for Neonatal Abstinence Syndrome Newborns.

Neonatal Abstinence Syndrome, Predictor Factors for Length of Stay.
A Brief Intervention for Mindfulness-Based Relapse Prevention in Primary Care: A Feasibility Pilot Study for Patients in Treatment for Opiate Addiction with Buprenorphine.

Integrated Community Care Model Supported by Telehealth Technology.


 
Geriatric Psychiatry:
A Phase 3 Safety and Efficacy Study of ALZT‐OP1 in Subjects with Evidence of Early Alzheimer’s Disease.

EARLY -
A Phase 2b/3 Randomized, Double-blind, Placebo-Controlled, Parallel Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects who are Asymptomatic At Risk for Developing Alzheimer’s Dementia.

A Randomized, Double-Blind, Placebo-Controlled and Delayed-Start Study of LY3314814 in Mild Alzheimer's Disease Dementia (The DAYBREAK Study).

HARMONY - A Double-blind, Placebo-controlled, Relapse Prevention Study of Pimavanserin for the Treatment of Hallucinations and Delusions Associated With Dementia-related Psychosis.

A Phase 2A Multicenter, Randomized, Double-blind, Parallel Group, 26-Week, Placebo-controlled Study of 50 mg and 100 mg of SUVN-502 in Subjects with Moderate Alzheimer's Disease Currently Treated with Donepezil Hydrochloride and Memantine Hydrochloride.

A 52-Week Open-label Extension Study of Pimavanserin for the Treatment of Agitation and Aggression in Subjects with Alzheimer's Disease.

Long-term Nicotine Treatment of Mild Cognitive Impairment.

 
Disabilities of the Arm, Shoulder, and Hand (DASH) - Validity and Reliability among Patients Recovering from Stroke.

 
Integrated Community Care Model Supported by Telehealth Technology.
The Emergency Surgery Score (ESS): A Prospective Multicenter Validation of ESS as a Tool to Predict Postoperative Mortality and Complications after Emergency General Surgery.

American College of Surgeons Trauma Quality Improvement Program (ACS TQIP®).
Post-Approval Study of Transcarotid Artery Revascularization in Patients with Significant Carotid Artery Disease (The ROADSTER 2 Study).

GREAT - Global Registry for Endovascular Aortic Treatment Outcomes Evaluation.